Use Our Juice-C Vitamin C + Organic Berries Serum after you cleanse and tone your face, but before you moisturize. Drop one or two drops of serum on your face. Gentle and thoroughly rub into your face using upward, circular motion. You can use the serum once or twice daily in the morning and night. We recommend that if you are using any of our products that contain Niacinamide, that you alter the time of day you are using your Juice-C serum. In this case, you can use Juice-C in the morning and any products with Niacinamide at night.